The PhD activity will offer an opportunity for motivated candidates to embark on a PhD journey delving into the realm of next-generation serious games (SGs) infused with Artificial Intelligence (AI). Focused on revolutionizing game development, particularly in educational and sustainability domains, the main aim is to explore the transformative potential of AI advancements. By exploiting AI-driven capabilities, SGs can dynamically adapt to individual player profiles, fostering deeper engagement and immersion. Central to this initiative is the concept of human-AI collaboration, where AI systems seamlessly integrate with human players to provide tailored and challenging experiences. The PhD grant sets out to achieve key objectives including AI-driven content generation, adaptive gameplay mechanisms, personalized game experiences, and collaborative human-AI interaction. Moreover, it addresses ethical and societal implications, ensuring responsible and inclusive game design. Through interdisciplinary research and European collaborations, the PhD activity aims to advance AI-driven serious game development, creating a new generation of impactful and immersive SGs.